Human IL-16 protein (Recombinant) (His-Tag) (STJP019686)

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STJP019686
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL-16-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL16
Gene ID: 3603
Uniprot ID: IL16_HUMAN
Immunogen Region: 502-631aa
Accession Number: NP_004504.3
Immunogen: Human
Immunogen Sequence: MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS
Tissue Specificity Isoform 3: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation.
Post Translational Modifications Isoform 3: Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16.
Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1: May act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Protein Name Pro-Interleukin-16 Cleaved Into - Interleukin-16
Il-16
Lymphocyte Chemoattractant Factor
Lcf
Database Links Reactome: R-HSA-449836
Cellular Localisation Interleukin-16: Secreted
Isoform 1: Cytoplasm
Isoform 3: Cytoplasm
Nucleus
Alternative Protein Names Pro-Interleukin-16 Cleaved Into - Interleukin-16 protein
Il-16 protein
Lymphocyte Chemoattractant Factor protein
Lcf protein
IL16 protein

Information sourced from Uniprot.org

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