• Biotinylated Human IL-15RA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human IL-15RA is greater than 95% as determined by SEC-HPLC.
  • Immobilized Human IL-15 at 0. 5 Mu g/ml (100 Mu l/Well) on the plate. Dose response curve for Biotinylated Human IL-15RA, His Tag with the EC50 of 18. 1ng/ml determined by ELISA.

Human IL-15RA/IL-15 R alpha/CD215 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001659)

SKU:
STJP001659

£618.50 - £1,909.50
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IL-15RA/IL-15 R alpha/CD215-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: IL15RA
Gene ID: 3601
Uniprot ID: I15RA_HUMAN
Immunogen Region: Ile31-Thr205
Immunogen: DNA sequence encoding Human IL-15RA/IL-15 R alpha/CD215 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Post Translational Modifications N-glycosylated and O-glycosylated. A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.
Function High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5: Does not bind IL15. Isoform 6: Does not bind IL15. Isoform 7: Does not bind IL15. Isoform 8: Does not bind IL15.
Protein Name Interleukin-15 Receptor Subunit Alpha
Il-15 Receptor Subunit Alpha
Il-15r-Alpha
Il-15ra
Cd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha
Sil-15 Receptor Subunit Alpha
Sil-15r-Alpha
Sil-15ra
Database Links Reactome: R-HSA-8983432
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Nucleus Membrane
Cell Surface
Mainly Found Associated With The Nuclear Membrane
Isoform 5: Endoplasmic Reticulum Membrane
Golgi Apparatus Membrane
Cytoplasmic Vesicle Membrane
Isoform 5
Isoform 6
Isoform 7 And Isoform 8 Are Associated With Endoplasmic Reticulum
Golgi And Cytoplasmic Vesicles
But Not With The Nuclear Membrane
Isoform 6: Endoplasmic Reticulum Membrane
Isoform 7: Endoplasmic Reticulum Membrane
Isoform 8: Endoplasmic Reticulum Membrane
Soluble Interleukin-15 Receptor Subunit Alpha: Secreted
Extracellular Space
Alternative Protein Names Interleukin-15 Receptor Subunit Alpha protein
Il-15 Receptor Subunit Alpha protein
Il-15r-Alpha protein
Il-15ra protein
Cd Antigen Cd215 Cleaved Into - Soluble Interleukin-15 Receptor Subunit Alpha protein
Sil-15 Receptor Subunit Alpha protein
Sil-15r-Alpha protein
Sil-15ra protein
IL15RA protein

Information sourced from Uniprot.org

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