Human IL-13R alpha 2/IL13RA2 protein (Recombinant) (His-Tag) (STJP018246)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human IL-13R alpha 2/IL13RA2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL13RA2 |
| Gene ID | 3598 |
| Uniprot ID | I13R2_HUMAN |
| Accession Number | NP_000631 |
| Immunogen | Human |
| Immunogen Region | 27-343aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Cleaved by MMP8 leading to a soluble form that is also able to interact with IL13. |
| Function | Cell surface receptor that plays a role in the regulation of IL-13-mediated responses. Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation. Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1. |
| Protein Name | Interleukin-13 Receptor Subunit Alpha-2Il-13 Receptor Subunit Alpha-2Il-13r Subunit Alpha-2Il-13r-Alpha-2Il-13ra2Interleukin-13-Binding ProteinCd Antigen Cd213a2 |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-13 Receptor Subunit Alpha-2 proteinIl-13 Receptor Subunit Alpha-2 proteinIl-13r Subunit Alpha-2 proteinIl-13r-Alpha-2 proteinIl-13ra2 proteinInterleukin-13-Binding Protein proteinCd Antigen Cd213a2 proteinIL13RA2 proteinIL13R protein |
Information sourced from Uniprot.org