Human IL-12 R beta 1/CD212 protein (Recombinant) (C-His) (STJP019902)

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STJP019902-100
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Covered by St John's Laboratory Guarantee

Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 1 EU/Mu g of the protein by LAL method.
Gene Symbol: IL12RB1
Gene ID: 3594
Uniprot ID: I12R1_HUMAN
Immunogen Region: Cys24-Glu540
Immunogen: Recombinant Human IL-12 R beta 1/CD212 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys24-Glu540) of Human IL-12 R beta 1/CD212 (Accession #P42701-1) fused with a C-His tag at the C-terminus.
Immunogen Sequence: CRTSECCFQDPPYPDADSGS ASGPRDLRCYRISSDRYECS WQYEGPTAGVSHFLRCCLSS GRCCYFAAGSATRLQFSDQA GVSVLYTVTLWVESWARNQT EKSPEVTLQLYNSVKYEPPL GDIKVSKLAGQLRMEWETPD NQVGAEVQFRHRTPSSPWKL GDCGPQDDDTESCLCPLEMN VAQEFQLRRRQLGSQGSSWS KWSSPVCVPPENPPQPQVRF SVEQLGQDGRRRLTLKEQP
Function Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Protein Name Interleukin-12 Receptor Subunit Beta-1
Il-12 Receptor Subunit Beta-1
Il-12r Subunit Beta-1
Il-12r-Beta-1
Il-12rb1
Il-12 Receptor Beta Component
Cd Antigen Cd212
Database Links Reactome: R-HSA-9020591
Reactome: R-HSA-9020933
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Interleukin-12 Receptor Subunit Beta-1 protein
Il-12 Receptor Subunit Beta-1 protein
Il-12r Subunit Beta-1 protein
Il-12r-Beta-1 protein
Il-12rb1 protein
Il-12 Receptor Beta Component protein
Cd Antigen Cd212 protein
IL12RB1 protein
IL12R protein
IL12RB protein

Information sourced from Uniprot.org

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