Human IL-11 receptor alpha protein (Recombinant) (STJP000609)

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STJP000609
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IL-11 receptor alpha-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution pH7.4.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was determined by its ability to bind Human IL-6ST in functional ELISA. NA
Gene Symbol: IL11RA
Gene ID: 3590
Uniprot ID: I11RA_HUMAN
Immunogen Region: ECD
Immunogen: DNA sequence encoding extracellular domain of human IL-11RA fused to a C-terminal polyHis tag was expressed in HEK cells. NA
Immunogen Sequence: MSSSCSGLSR VLVAVATALV SASSPCPQAW GPPGVQYGQP GRSVKLCCPG VTAGDPVSWF RDGEPKLLQG PDSGLGHELV LAQADSTDEG TYICQTLDGA LGGTVTLQLG YPPARPVVSC QAADYENFSC TWSPSQISGL PTRYLTSYRK KTVLGADSQR RSPSTGPWPC PQDPLGAARC VVHGAEFWSQ YRINVTEVNP LGASTRLLDV SLQSILRPDP PQGLRVES
Tissue Specificity Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.
Post Translational Modifications A short soluble form is also released from the membrane by proteolysis. The sIL11RA is formed either by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding, or directly secreted from the cells after alternative mRNA splicing. mIL11RA is cleaved by the proteases ADAM10, ELANE and PRTN3.
Function Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Soluble interleukin-11 receptor subunit alpha: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling. Isoform HCR2: Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
Protein Name Interleukin-11 Receptor Subunit Alpha
Il-11 Receptor Subunit Alpha
Il-11r Subunit Alpha
Il-11r-Alpha
Il-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha
Sil-11r
Sil-11ra
Sil11ra
Database Links Reactome: R-HSA-6788467
Cellular Localisation Interleukin-11 Receptor Subunit Alpha: Membrane
Single-Pass Type I Membrane Protein
Soluble Interleukin-11 Receptor Subunit Alpha: Secreted
Isoform Hcr2: Secreted
Alternative Protein Names Interleukin-11 Receptor Subunit Alpha protein
Il-11 Receptor Subunit Alpha protein
Il-11r Subunit Alpha protein
Il-11r-Alpha protein
Il-11ra Cleaved Into - Soluble Interleukin-11 Receptor Subunit Alpha protein
Sil-11r protein
Sil-11ra protein
Sil11ra protein
IL11RA protein

Information sourced from Uniprot.org

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