| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human IL-1 receptor type II (CD121b)-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Storage Instruction: |
Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Immunoreactivity: |
Recombinant Human IL-1 receptor type 2 activity was measured by its ability to inhibit IL-1b dependent proliferation in mouse helper T cells. The ED50 for this effect is typically 5 Mu g/mL in the presence of 40 pg/mL of human IL-1b. NA |
| Gene Symbol: |
IL1R2 |
| Gene ID: |
7850 |
| Uniprot ID: |
IL1R2_HUMAN |
| Immunogen Region: |
ECD |
| Immunogen: |
Optimized DNA sequence encoding Human extracellular domain of human IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells. NA |
| Post Translational Modifications | A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase.hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported. |
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Protein Name | Interleukin-1 Receptor Type 2Il-1r-2Il-1rt-2Il-1rt2Cd121 Antigen-Like Family Member BCdw121bIl-1 Type Ii ReceptorInterleukin-1 Receptor BetaIl-1r-BetaInterleukin-1 Receptor Type IiCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane FormMil-1r2Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble FormSil-1r2Sil-1rii |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform Short: SecretedIsoform Long: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Interleukin-1 Receptor Type 2 proteinIl-1r-2 proteinIl-1rt-2 proteinIl-1rt2 proteinCd121 Antigen-Like Family Member B proteinCdw121b proteinIl-1 Type Ii Receptor proteinInterleukin-1 Receptor Beta proteinIl-1r-Beta proteinInterleukin-1 Receptor Type Ii proteinCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form proteinMil-1r2 proteinMil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form proteinSil-1r2 proteinSil-1rii proteinIL1R2 proteinIL1RB protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
