Human IKZF3 protein (Recombinant) (N-His) (STJP011030)

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STJP011030
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human IKZF3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: IKZF3
Gene ID: 22806
Uniprot ID: IKZF3_HUMAN
Immunogen Region: Glu84-Thr326
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
Function Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Protein Name Zinc Finger Protein Aiolos
Ikaros Family Zinc Finger Protein 3
Cellular Localisation Nucleus
Cytoplasm
Isoform 1: Nucleus
Isoform 3: Nucleus
Isoform 11: Nucleus
Isoform 14: Nucleus
Isoform 12: Cytoplasm
Alternative Protein Names Zinc Finger Protein Aiolos protein
Ikaros Family Zinc Finger Protein 3 protein
IKZF3 protein
ZNFN1A3 protein

Information sourced from Uniprot.org

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