| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human IgG2A-NO-tag protein was developed from hek293 cells and has a target region of NO-tag. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA.Immobilized Human CD32a (Catalog: RP00081) at 2 Mu g/mL (100 Mu L/well) can bind Human IgG2 (Catalog: RPT0005) with a linear range of 1.2-338 ng/mL. |
| Gene Symbol: |
IGHG2Uniprot ID=IGHG2_HUMAN" |
| Immunogen Region: |
Glu99-Lys326 |
| Immunogen: |
Recombinant Human IgG2A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu99-Lys326) of human IgG2A (Accession #) fused with and NO-tag at the C-terminus. |
| Function | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. |
| Protein Name | Immunoglobulin Heavy Constant Gamma 2Ig Gamma-2 Chain C RegionIg Gamma-2 Chain C Region DotIg Gamma-2 Chain C Region TilIg Gamma-2 Chain C Region Zie |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Cell MembraneSingle-Pass Membrane Protein |
| Alternative Protein Names | Immunoglobulin Heavy Constant Gamma 2 proteinIg Gamma-2 Chain C Region proteinIg Gamma-2 Chain C Region Dot proteinIg Gamma-2 Chain C Region Til proteinIg Gamma-2 Chain C Region Zie proteinIGHG2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
