| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human IgG1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human Fc-gamma RII-a (CD32a) at 1 Mu g/mL (100 Mu L/well) can bind IgG1 Fc with a linear range of 0.156-3.47 Mu g/mL. |
| Gene Symbol: |
IGHG1Uniprot ID=IGHG1_HUMAN" |
| Immunogen Region: |
Pro100-Lys330 |
| Immunogen: |
Recombinant Human IgG1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Pro100-Lys330) of human IgG1 Fc fused with a 6×His tag at the C-terminus. |
| Function | Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen. Mediates IgG effector functions on monocytes triggering ADCC of virus-infected cells. |
| Protein Name | Immunoglobulin Heavy Constant Gamma 1Ig Gamma-1 Chain C RegionIg Gamma-1 Chain C Region EuIg Gamma-1 Chain C Region KolIg Gamma-1 Chain C Region Nie |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Cell MembraneSingle-Pass Membrane Protein |
| Alternative Protein Names | Immunoglobulin Heavy Constant Gamma 1 proteinIg Gamma-1 Chain C Region proteinIg Gamma-1 Chain C Region Eu proteinIg Gamma-1 Chain C Region Kol proteinIg Gamma-1 Chain C Region Nie proteinIGHG1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
