• Human IGFBP-1 protein (Recombinant) (C-His) (STJP001006)
  • Human IGFBP-1 protein (Recombinant) (C-His) (STJP001006)
  • Human IGFBP-1 protein (Recombinant) (C-His) (STJP001006)
  • Human IGFBP-1 protein (Recombinant) (C-His) (STJP001006)

Human IGFBP-1 protein (Recombinant) (C-His) (STJP001006)

SKU:
STJP001006

£89.50 - £298.50
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human IGFBP-1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IGFBP-1 at 5 Mu g/mL (100 Mu L/well) can bind Recombinant Human IGF1 with a linear range of 44-176 ng/mL.
Gene Symbol: IGFBP1
Gene ID: 3484
Uniprot ID: IBP1_HUMAN
Immunogen Region: Ala26-Asn259
Immunogen: Recombinant Human IGFBP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala26-Asn259) of human IGFBP-1 (Accession #NP_000587.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Phosphorylated.probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.
Function IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.
Protein Name Insulin-Like Growth Factor-Binding Protein 1
Ibp-1
Igf-Binding Protein 1
Igfbp-1
Placental Protein 12
Pp12
Database Links Reactome: R-HSA-380994
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Reactome: R-HSA-9615017
Cellular Localisation Secreted
Alternative Protein Names Insulin-Like Growth Factor-Binding Protein 1 protein
Ibp-1 protein
Igf-Binding Protein 1 protein
Igfbp-1 protein
Placental Protein 12 protein
Pp12 protein
IGFBP1 protein
IBP1 protein

Information sourced from Uniprot.org

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