| Function | Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. |
| Protein Name | Cation-Independent Mannose-6-Phosphate ReceptorCi Man-6-P ReceptorCi-MprM6pr300 Kda Mannose 6-Phosphate ReceptorMpr 300Insulin-Like Growth Factor 2 ReceptorInsulin-Like Growth Factor Ii ReceptorIgf-Ii ReceptorM6p/Igf2 ReceptorM6p/Igf2rCd Antigen Cd222 |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-6798695Reactome: R-HSA-6811440Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneMainly Localized In The Golgi At Steady State And Not Detectable In LysosomeColocalized With Dpp4 In Internalized Cytoplasmic Vesicles Adjacent To The Cell Surface |
| Alternative Antibody Pair Names | Cation-Independent Mannose-6-Phosphate Receptor antibody pairCi Man-6-P Receptor antibody pairCi-Mpr antibody pairM6pr antibody pair300 Kda Mannose 6-Phosphate Receptor antibody pairMpr 300 antibody pairInsulin-Like Growth Factor 2 Receptor antibody pairInsulin-Like Growth Factor Ii Receptor antibody pairIgf-Ii Receptor antibody pairM6p/Igf2 Receptor antibody pairM6p/Igf2r antibody pairCd Antigen Cd222 antibody pairIGF2R antibody pairMPRI antibody pair |
Information sourced from Uniprot.org
