SDS-PAGE gel of recombinant human IFT20 protein under reducing conditions stained with Coomassie blue

Human IFT20 protein (Recombinant) (His-Tag) (STJP017831)

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STJP017831
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Short Description :Recombinant-Human IFT20-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:IFT20
Gene ID:90410
Uniprot ID:IFT20_HUMAN
Accession Number:AAH38094
Immunogen:Human
Immunogen Region:1-132aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MAKDILGEAG LHFDELNKLR VLDPEVTQQT IELKEECKDF VDKIGQFQKI VGGLIELVDQ LAKEAENEKM KAIGARNLLK SIAKQREAQQ QQLQALIAEK KMQLERYRVE YEALCKVEAE QNEFIDQFIF QK
Tissue Specificity Expressed in almost all tissues.
Function Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
Protein Name Intraflagellar Transport Protein 20 Homolog
Hift20
Database Links Reactome: R-HSA-5620924
Cellular Localisation Golgi Apparatus
Cis-Golgi Network
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriole
Cilium Basal Body
Cell Projection
Cilium
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
Present At The Centrosomes During The Cell Cycle And Associated With The Proximal Portion Of The Mother Centriole And The Lateral Aspect Of The Daughter Centriole
Associated With Basal Body At The Base Of Primary Cilia
Detected In The Golgi Apparatus Of Round Spermatids And Late Spermatocytes
Also Detected In The Manchette Of Step 10-12 Spermatids
In Step 14 Spermatids
Found In The Basal Body Of The Sperm Tail
Localization In The Manchette Of Elongating Spermatids Is Dependent On Spag17
Alternative Protein Names Intraflagellar Transport Protein 20 Homolog protein
Hift20 protein
IFT20 protein

Information sourced from Uniprot.org

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