| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth. |
| Protein Name | Interferon BetaIfn-BetaFibroblast Interferon |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-918233Reactome: R-HSA-933541Reactome: R-HSA-9705671Reactome: R-HSA-983231Reactome: R-HSA-9833109 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Interferon Beta ELISA kitIfn-Beta ELISA kitFibroblast Interferon ELISA kitIFNB1 ELISA kitIFB ELISA kitIFNB ELISA kit |
| output | |
Information sourced from Uniprot.org
