Name: Human IFN-gamma R1/CD119 protein (Recombinant) (C-His) (STJP002598)
SKU: STJP002598
Availability: InStock

Human IFN-gamma R1/CD119 protein (Recombinant) (C-His) (STJP002598)

SKU:

STJP002598

£71.50 - £185.50

Short Description :	Recombinant-Human IFN-gamma R1/CD119-C-His protein was developed in hek293 cells using the region Met1-Gly245. For use in research applications.
Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Conjugation:	Unconjugated
Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human FNGR1/CD119 at 1 Mu g/mL (100 Mu L/well) can bind Human IFNG with a linear range of 0.98-1.97 ng/mL.
Determination Method:	< 0.1 EU/Mu g of the protein by LAL method.

Gene Symbol:	IFNGR1
Gene ID:	3459
Uniprot ID:	INGR1_HUMAN
Immunogen:	Recombinant Human IFN-gamma R1/CD119 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Gly245) of human IFNGR1/CD119 (Accession #NP_000407.1) fused with a 6×His tag at the C-terminus.
Immunogen Region:	Met1-Gly245
Immunogen Sequence:	MALLFLLPLVMQGVSRAEMG TADLGPSSVPTPTNVTIESY NMNPIVYWEYQIMPQVPVFT VEVKNYGVKNSEWIDACINI SHHYCNISDHVGDPSNSLWV RVKARVGQKESAYAKSEEFA VCRDGKIGPPKLDIRKEEKQ IMIDIFHPSVFVNGDEQEVD YDPETTCYIRVYNVYVRMNG SEIQYKILTQKEDDCDEIQC QLAIPVSSLNSQYCVSAEGV LHVWGVTTEKSKEVCITIF

Function	Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Associates with transmembrane accessory factor IFNGR2 to form a functional receptor. Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription. STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1.
Protein Name	Interferon Gamma Receptor 1 Ifn-Gamma Receptor 1 Ifn-Gamma-R1 Cdw119 Interferon Gamma Receptor Alpha-Chain Ifn-Gamma-R-Alpha Cd Antigen Cd119
Database Links	Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-9679191 Reactome: R-HSA-9732724
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Interferon Gamma Receptor 1 protein Ifn-Gamma Receptor 1 protein Ifn-Gamma-R1 protein Cdw119 protein Interferon Gamma Receptor Alpha-Chain protein Ifn-Gamma-R-Alpha protein Cd Antigen Cd119 protein IFNGR1 protein

Information sourced from Uniprot.org

Model	Name	Host	Application
STJP020172	Human IFN-gamma protein (Recombinant) (C-His&Avi) {Biotin} (STJP020172)	HEK293 cells
STJP001590	Human IFN gamma/IFNG protein (Recombinant) (C-His-Avi) {Biotin} (STJP001590)	HEK293
STJP004130	Human CD119/IFNGR1 protein (Recombinant) (C-His) (STJP004130)	Mammalian Cells	ELISA/Immunogen/SDS-PAGE/WB
STJP001758	Human IFN alpha/beta R1 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001758)	HEK293
STJP013789	Mouse IFNG/IFN-gamma protein (Recombinant) (C-His) (STJP013789)	Mammalian Cells	ELISA/WB

Human IFN-gamma R1/CD119 protein (Recombinant) (C-His) (STJP002598)

General Information