| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of 25mM NaAc PH 5.0 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.01 EU/Mu g |
| Gene Symbol: |
IFNB1 |
| Gene ID: |
3456 |
| Uniprot ID: |
IFNB_HUMAN |
| Immunogen Region: |
Met22-Asn187 |
| Immunogen: |
Recombinant Human IFN-beta Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met22-Asn187) of human IFN-beta/IFNB1 (Accession #NP_002167.1) fused with no additional amino acid. |
| Immunogen Sequence: |
FDWQYINPVAHMKSSAWVNK IQVLMAAASFGQTKIPRGNG PYSVGCTDLMFDHTNKGTFL RLYYPSQDNDRLDTLWIPNK EYFWGLSKFLGTHWLMGNIL RLLFGSMTTPANWNSPLRPG EKYPLVVFSHGLGAFRTLYS AIGIDLASHGFIVAAVEHRD RSASATYYFKDQSAAEIGDK SWLYLRTLKQEEETHIRNEQ VRQRAKECSQALSLILDIDH GKPVKNALDLKFDMEQLKD |
| Function | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth. |
| Protein Name | Interferon BetaIfn-BetaFibroblast Interferon |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-918233Reactome: R-HSA-933541Reactome: R-HSA-9705671Reactome: R-HSA-983231Reactome: R-HSA-9833109 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interferon Beta proteinIfn-Beta proteinFibroblast Interferon proteinIFNB1 proteinIFB proteinIFNB protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
