Human IFIT3 protein (Recombinant) (N-His) (STJP010634)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IFIT3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IFIT3 |
| Gene ID | 3437 |
| Uniprot ID | IFIT3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ser467 |
Additional Info
| Function | IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. |
| Protein Name | Interferon-Induced Protein With Tetratricopeptide Repeats 3Ifit-3Cig49Isg-60Interferon-Induced 60 Kda ProteinIfi-60kInterferon-Induced Protein With Tetratricopeptide Repeats 4Ifit-4Retinoic Acid-Induced Gene G ProteinP60Rig-G |
| Database Links | Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Protein Names | Interferon-Induced Protein With Tetratricopeptide Repeats 3 proteinIfit-3 proteinCig49 proteinIsg-60 proteinInterferon-Induced 60 Kda Protein proteinIfi-60k proteinInterferon-Induced Protein With Tetratricopeptide Repeats 4 proteinIfit-4 proteinRetinoic Acid-Induced Gene G Protein proteinP60 proteinRig-G proteinIFIT3 proteinCIG-49 proteinIFI60 proteinIFIT4 proteinISG60 protein |
Information sourced from Uniprot.org