| Function | May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. |
| Protein Name | Radiation-Inducible Immediate-Early Gene Iex-1Differentiation-Dependent Gene 2 ProteinProtein Dif-2Immediate Early Protein Gly96Immediate Early Response 3 ProteinPacap-Responsive Gene 1 ProteinProtein Prg1 |
| Database Links | Reactome: R-HSA-6811558 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Radiation-Inducible Immediate-Early Gene Iex-1 proteinDifferentiation-Dependent Gene 2 Protein proteinProtein Dif-2 proteinImmediate Early Protein Gly96 proteinImmediate Early Response 3 Protein proteinPacap-Responsive Gene 1 Protein proteinProtein Prg1 proteinIER3 proteinDIF2 proteinIEX1 proteinPRG1 protein |
Information sourced from Uniprot.org