| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.057ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This ICOSLG Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | ICOSLG |
| Gene ID: | 23308 |
| Uniprot ID: | ICOSL_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Expressed on peripheral blood B-cells and monocytes, as well as on monocyte-derived dendritic cells (at protein level). Isoform 1: Widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil). Isoform 2: Detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. |
| Post Translational Modifications | |
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion. Also induces B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. In endothelial cells, required for proper neutrophil transmigration in response to chemoattractants, such as CXCL8/IL8 or N-formyl-methionyl peptides (fMLP). |
| Protein Name | Icos Ligand B7 Homolog 2 B7-H2 B7-Like Protein Gl50 B7-Related Protein 1 B7rp-1 Cd Antigen Cd275 |
| Database Links | Reactome: R-HSA-388841 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cell Membrane |
| Alternative ELISA Names | Icos Ligand ELISA kit B7 Homolog 2 ELISA kit B7-H2 ELISA kit B7-Like Protein Gl50 ELISA kit B7-Related Protein 1 ELISA kit B7rp-1 ELISA kit Cd Antigen Cd275 ELISA kit ICOSLG ELISA kit B7H2 ELISA kit B7RP1 ELISA kit ICOSL ELISA kit KIAA0653 ELISA kit |
| output |
Information sourced from Uniprot.org
