• Human HTRA2 protein (Recombinant) (No tag) (STJP000816)

Human HTRA2 protein (Recombinant) (No tag) (STJP000816)

SKU:
STJP000816

£59.50 - £105.50
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Host: E. coli
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human HTRA2-No tag protein was developed from e. coli and has a target region of No tag. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of 20mM TRIS, 150mM NaCl, pH 8.0. Contact us for customized product form or formulation.
Endotoxin: Please contact us for more information.
Immunoreactivity: Protease activity demonstrated by HtrA2 cleavage of bovine Beta-casein (Sigma, Catalog # C-6905). Incubation of Beta-casein at 0.2 mg/mL with Recombinant Human HTRA-2 at 0.02 mg/mL (ratio of 10:1) for 60 minutes at 45 °C in 50 mM Tris, pH 8.0, which
Gene Symbol: HTRA2
Gene ID: 27429
Uniprot ID: HTRA2_HUMAN
Immunogen Region: Ala134-Glu458
Immunogen: Recombinant Human HTRA2 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala134-Glu458) of human HTRA2/Omi (Accession #NP_037379.1).
Tissue Specificity Isoform 1: Ubiquitously expressed.
Post Translational Modifications Autoproteolytically activated.
Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Protein Name Serine Protease Htra2 - Mitochondrial
High Temperature Requirement Protein A2
Htra2
Omi Stress-Regulated Endoprotease
Serine Protease 25
Serine Proteinase Omi
Cellular Localisation Mitochondrion Intermembrane Space
Mitochondrion Membrane
Single-Pass Membrane Protein
Predominantly Present In The Intermembrane Space
Released Into The Cytosol Following Apoptotic Stimuli
Such As Uv Treatment
And Stimulation Of Mitochondria With Caspase-8 Truncated Bid/Tbid
Isoform 1: Endoplasmic Reticulum
Alternative Protein Names Serine Protease Htra2 - Mitochondrial protein
High Temperature Requirement Protein A2 protein
Htra2 protein
Omi Stress-Regulated Endoprotease protein
Serine Protease 25 protein
Serine Proteinase Omi protein
HTRA2 protein
OMI protein
PRSS25 protein

Information sourced from Uniprot.org

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