• Human HTRA2 protein (Recombinant) (No tag) (STJP000816)

Human HTRA2 protein (Recombinant) (No tag) (STJP000816)

SKU:
STJP000816

£64.50 - £148.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: Please contact us for more information.
Immunoreactivity: Protease activity demonstrated by HtrA2 cleavage of bovine Beta-casein (Sigma, Catalog # C-6905). Incubation of Beta-casein at 0.2 mg/mL with Recombinant Human HTRA-2 at 0.02 mg/mL (ratio of 10:1) for 60 minutes at 45 °C in 50 mM Tris, pH 8.0, which
Gene Symbol: HTRA2
Gene ID: 27429
Uniprot ID: HTRA2_HUMAN
Immunogen Region: Ala134-Glu458
Immunogen: Recombinant Human HTRA2 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala134-Glu458) of human HTRA2/Omi (Accession #NP_037379.1).
Immunogen Sequence: AVPSPPPASPRSQYNFIADV VEKTAPAVVYIEILDRHPFL GREVPISNGSGFVVAADGLI VTNAHVVADRRRVRVRLLSG DTYEAVVTAVDPVADIATLR IQTKEPLPTLPLGRSADVRQ GEFVVAMGSPFALQNTITSG IVSSAQRPARDLGLPQTNVE YIQTDAAIDFGNSGGPLVNL DGEVIGVNTMKVTAGISFAI PSDRLREFLHRGEKKNSSSG ISGSQRRYIGVMMLTLSPS
Tissue Specificity Isoform 1: Ubiquitously expressed.
Post Translational Modifications Ubiquitinated by BIRC6.this activity is inhibited by DIABLO/SMAC. Autoproteolytically activated.
Function Isoform 1: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes apoptosis by either relieving the inhibition of BIRC proteins on caspases, leading to an increase in caspase activity.or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves BIRC6 and relieves its inhibition on CASP3, CASP7 and CASP9, but it is also prone to inhibition by BIRC6. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2: Seems to be proteolytically inactive.
Protein Name Serine Protease Htra2 - Mitochondrial
High Temperature Requirement Protein A2
Htra2
Omi Stress-Regulated Endoprotease
Serine Protease 25
Serine Proteinase Omi
Database Links Reactome: R-HSA-9837999
Cellular Localisation Mitochondrion Intermembrane Space
Mitochondrion Membrane
Single-Pass Membrane Protein
Predominantly Present In The Intermembrane Space
Released Into The Cytosol Following Apoptotic Stimuli
Such As Uv Treatment
And Stimulation Of Mitochondria With Caspase-8 Truncated Bid/Tbid
Isoform 1: Endoplasmic Reticulum
Alternative Protein Names Serine Protease Htra2 - Mitochondrial protein
High Temperature Requirement Protein A2 protein
Htra2 protein
Omi Stress-Regulated Endoprotease protein
Serine Protease 25 protein
Serine Proteinase Omi protein
HTRA2 protein
OMI protein
PRSS25 protein

Information sourced from Uniprot.org

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