Human HSPB11 protein (Recombinant) (His-Tag) (STJP017196)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HSPB11-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 2mM DTT, 0.1M NaCl. |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IFT25 |
| Gene ID | 51668 |
| Uniprot ID | IFT25_HUMAN |
| Accession Number | NP_057210 |
| Immunogen | Human |
| Immunogen Region | 1-144aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MRKIDLCLSS EGSEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI ICFHKHVRIE RLVIQSYFVQ TLKIEKSTSK EPVDFEQWIE KDLVHTEGQL QNEEIVAHDG SATYLRFIIV SAFDHFASVH SVSAEGTVVS NLSS |
Additional Info
| Tissue Specificity | Detected in placenta. |
| Function | Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation. |
| Protein Name | Intraflagellar Transport Protein 25 HomologHeat Shock Protein Beta-11Hspb11Heat Shock Protein Family B Member 11Placental Protein 25Pp25 |
| Database Links | Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell ProjectionCilium |
| Alternative Protein Names | Intraflagellar Transport Protein 25 Homolog proteinHeat Shock Protein Beta-11 proteinHspb11 proteinHeat Shock Protein Family B Member 11 proteinPlacental Protein 25 proteinPp25 proteinIFT25 proteinC1orf41 proteinHSPB11 proteinHSPC034 protein |
Information sourced from Uniprot.org