Human HSP20/HSPB6 protein (Recombinant) (His-Tag) (STJP019095)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HSP20/HSPB6-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 30% Glycerol, 1mM DTT, 1mM EDTA, 0.1mM PMSF |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HSPB6 |
| Gene ID | 126393 |
| Uniprot ID | HSPB6_HUMAN |
| Accession Number | NP_653218 |
| Immunogen | Human |
| Immunogen Region | 1-160aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSHMEIPVP VQPSWLRRAS APLPGLSAPG RLFDQRFGEG LLEAELAALC PTTLAPYYLR APSVALPVAQ VPTDPGHFSV LLDVKHFSPE EIAVKVVGEH VEVHARHEER PDEHGFVARE FHRRYRLPPG VDPAAVTSAL SPEGVLSIQA APASAQAPPP AAAK |
Additional Info
| Post Translational Modifications | The N-terminus is blocked. Phosphorylated at Ser-16 by PKA and probably PKD1K.required to protect cardiomyocytes from apoptosis. |
| Function | Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. |
| Protein Name | Heat Shock Protein Beta-6Hspb6Heat Shock 20 Kda-Like Protein P20Heat Shock Protein Family B Member 6 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusSecretedTranslocates To Nuclear Foci During Heat Shock |
| Alternative Protein Names | Heat Shock Protein Beta-6 proteinHspb6 proteinHeat Shock 20 Kda-Like Protein P20 proteinHeat Shock Protein Family B Member 6 proteinHSPB6 protein |
Information sourced from Uniprot.org