Human HSD17B3 protein (Recombinant) (N-His) (STJP006615)

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STJP006615
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HSD17B3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HSD17B3
Gene ID: 3293
Uniprot ID: DHB3_HUMAN
Immunogen Region: Met1-Arg310
Immunogen: Homo sapiens (Human)
Function Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function. Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms.
Protein Name 17-Beta-Hydroxysteroid Dehydrogenase Type 3
17-Beta-Hsd 3
Estradiol 17-Beta-Dehydrogenase 2
Short Chain Dehydrogenase/Reductase Family 12c Member 2
Testicular 17-Beta-Hydroxysteroid Dehydrogenase
Testosterone 17-Beta-Dehydrogenase 3
Database Links Reactome: R-HSA-193048
Reactome: R-HSA-75876
Cellular Localisation Endoplasmic Reticulum
Alternative Protein Names 17-Beta-Hydroxysteroid Dehydrogenase Type 3 protein
17-Beta-Hsd 3 protein
Estradiol 17-Beta-Dehydrogenase 2 protein
Short Chain Dehydrogenase/Reductase Family 12c Member 2 protein
Testicular 17-Beta-Hydroxysteroid Dehydrogenase protein
Testosterone 17-Beta-Dehydrogenase 3 protein
HSD17B3 protein
EDH17B3 protein
SDR12C2 protein

Information sourced from Uniprot.org

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