Function | Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues. |
Protein Name | Heparan Sulfate 2-O-Sulfotransferase 12-O-Sulfotransferase2ost |
Database Links | Reactome: R-HSA-2022928 |
Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
Alternative Protein Names | Heparan Sulfate 2-O-Sulfotransferase 1 protein2-O-Sulfotransferase protein2ost proteinHS2ST1 proteinHS2ST proteinKIAA0448 protein |
Information sourced from Uniprot.org