| Function | Catalyzes the transfer of a sulfo group from 3'-phospho-5'-adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis. Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme. |
| Protein Name | Heparan Sulfate 2-O-Sulfotransferase 12-O-Sulfotransferase2-Ost2ostHs 2-O-SulfotransferaseHeparan Sulfate 2-Sulfotransferase |
| Database Links | Reactome: R-HSA-2022928 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Heparan Sulfate 2-O-Sulfotransferase 1 protein2-O-Sulfotransferase protein2-Ost protein2ost proteinHs 2-O-Sulfotransferase proteinHeparan Sulfate 2-Sulfotransferase proteinHS2ST1 proteinHS2ST proteinKIAA0448 protein |
Information sourced from Uniprot.org