Human HRSP12/RIDA protein (Recombinant) (His-Tag) (STJP016975)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human HRSP12/RIDA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.1M NaCl, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RIDA |
| Gene ID | 10247 |
| Uniprot ID | RIDA_HUMAN |
| Accession Number | NP_005827 |
| Immunogen | Human |
| Immunogen Region | 1-137aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MSSLIRRVIS TAKAPGAIGP YSQAVLVDRT IYISGQIGMD PSSGQLVSGG VAEEAKQALK NMGEILKAAG CDFTNVVKTT VLLADINDFN TVNEIYKQYF KSNFPARAAY QVAALPKGSR IEIEAVAIQG PLTTASL |
Additional Info
| Tissue Specificity | Expressed predominantly in liver and kidney. Lower levels in lung and brain. |
| Function | Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage. |
| Protein Name | 2-Iminobutanoate/2-Iminopropanoate Deaminase14.5 Kda Translational Inhibitor ProteinHp14.5P14.5Heat-Responsive Protein 12Reactive Intermediate Imine Deaminase A HomologTranslation Inhibitor L-Psp RibonucleaseUk114 Antigen Homolog |
| Database Links | Reactome: R-HSA-8849175 |
| Cellular Localisation | CytoplasmNucleusPeroxisomeMitochondrionMostly Cytoplasmic ButIn Less Differentiated Cells Occasionally Nuclear |
| Alternative Protein Names | 2-Iminobutanoate/2-Iminopropanoate Deaminase protein14.5 Kda Translational Inhibitor Protein proteinHp14.5 proteinP14.5 proteinHeat-Responsive Protein 12 proteinReactive Intermediate Imine Deaminase A Homolog proteinTranslation Inhibitor L-Psp Ribonuclease proteinUk114 Antigen Homolog proteinRIDA proteinHRSP12 protein |
Information sourced from Uniprot.org