Human HRSP12/RIDA protein (Recombinant) (His-Tag) (STJP016975)

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STJP016975
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HRSP12/RIDA-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 0.1M NaCl, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: RIDA
Gene ID: 10247
Uniprot ID: RIDA_HUMAN
Immunogen Region: 1-137aa
Accession Number: NP_005827
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MSSLIRRVIS TAKAPGAIGP YSQAVLVDRT IYISGQIGMD PSSGQLVSGG VAEEAKQALK NMGEILKAAG CDFTNVVKTT VLLADINDFN TVNEIYKQYF KSNFPARAAY QVAALPKGSR IEIEAVAIQG PLTTASL
Tissue Specificity Expressed predominantly in liver and kidney. Lower levels in lung and brain.
Function Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.
Protein Name 2-Iminobutanoate/2-Iminopropanoate Deaminase
14.5 Kda Translational Inhibitor Protein
Hp14.5
P14.5
Heat-Responsive Protein 12
Reactive Intermediate Imine Deaminase A Homolog
Translation Inhibitor L-Psp Ribonuclease
Uk114 Antigen Homolog
Database Links Reactome: R-HSA-8849175
Cellular Localisation Cytoplasm
Nucleus
Peroxisome
Mitochondrion
Mostly Cytoplasmic But
In Less Differentiated Cells Occasionally Nuclear
Alternative Protein Names 2-Iminobutanoate/2-Iminopropanoate Deaminase protein
14.5 Kda Translational Inhibitor Protein protein
Hp14.5 protein
P14.5 protein
Heat-Responsive Protein 12 protein
Reactive Intermediate Imine Deaminase A Homolog protein
Translation Inhibitor L-Psp Ribonuclease protein
Uk114 Antigen Homolog protein
RIDA protein
HRSP12 protein

Information sourced from Uniprot.org

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