Human HPGD protein (Recombinant) (C-His) (STJP013198)

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STJP013198-100
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Host: Mammalian Cells
Applications: ELISA/WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HPGD-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Conjugation: Unconjugated
Formulation: Supplied as a 0.22 Mu m filtered solution in 20mM HEPES, 150mM NaCl, pH 7.4.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: < 1 EU/µg as determined by LAL test.
Gene Symbol: HPGD
Gene ID: 3248
Uniprot ID: PGDH_HUMAN
Immunogen Region: Met1-Gln266
Immunogen: Homo sapiens (Human)
Function Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.
Protein Name 15-Hydroxyprostaglandin Dehydrogenase Nad(+
15-Pgdh
Eicosanoid/Docosanoid Dehydrogenase Nad(+
Prostaglandin Dehydrogenase 1
Short Chain Dehydrogenase/Reductase Family 36c Member 1
Database Links Reactome: R-HSA-2142700
Reactome: R-HSA-2162123
Reactome: R-HSA-9018676
Reactome: R-HSA-9018896
Cellular Localisation Cytoplasm
Alternative Protein Names 15-Hydroxyprostaglandin Dehydrogenase Nad(+ protein
15-Pgdh protein
Eicosanoid/Docosanoid Dehydrogenase Nad(+ protein
Prostaglandin Dehydrogenase 1 protein
Short Chain Dehydrogenase/Reductase Family 36c Member 1 protein
HPGD protein
PGDH1 protein
SDR36C1 protein

Information sourced from Uniprot.org

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