| Post Translational Modifications | Phosphorylated at Ser-377 in a SPO11-dependent manner. |
| Function | Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. |
| Protein Name | Horma Domain-Containing Protein 1Cancer/Testis Antigen 46Ct46Newborn Ovary Horma Protein |
| Cellular Localisation | NucleusChromosomePreferentially Localizes To Unsynapsed Or Desynapsed Chromosomal Regions During The Prophase I Stage Of MeiosisTrip13 Is Required For Depletion From Synapsed ChromosomesThe Expression Of The Phosphorylated Form At Ser-377 Is Restricted To Unsynapsed Chromosomal Regions |
| Alternative Protein Names | Horma Domain-Containing Protein 1 proteinCancer/Testis Antigen 46 proteinCt46 proteinNewborn Ovary Horma Protein proteinHORMAD1 proteinNOHMA protein |
Information sourced from Uniprot.org
