| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human HMGCS2-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | Please contact us for further information. |
| Gene Symbol: | HMGCS2 |
| Gene ID: | 3158 |
| Uniprot ID: | HMCS2_HUMAN |
| Immunogen Region: | Thr38-Val508 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity. |
| Function | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. |
| Protein Name | Hydroxymethylglutaryl-Coa Synthase - MitochondrialHmg-Coa Synthase3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-77111Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion |
| Alternative Protein Names | Hydroxymethylglutaryl-Coa Synthase - Mitochondrial proteinHmg-Coa Synthase protein3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase proteinHMGCS2 protein |
Information sourced from Uniprot.org