SDS-PAGE gel of recombinant human HMGB3 protein under reducing conditions stained with Coomassie blue

Human HMGB3 protein (Recombinant) (His-Tag) (STJP018343)

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STJP018343
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Short Description :Recombinant-Human HMGB3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:HMGB3
Gene ID:3149
Uniprot ID:HMGB3_HUMAN
Accession Number:NP_005333
Immunogen:Human
Immunogen Region:1-180aa
Immunogen Sequence:MAKGDPK KPKGKMSAYA FFVQTCREEH KKKNPEVPVN FAEFSKKCSE RWKTMSGKEK SKFDEMAKAD KVRYDREMKD YGPAKGGKKK KDPNAPKRPP SGFFLFCSEF RPKIKSTNPG ISIGDVAKKL GEMWNNLNDS EKQPYITKAA KLKEKYEKDV ADYKSKGKFD GAKGPAKVAR KKV
Tissue Specificity Expressed predominantly in placenta.
Post Translational Modifications Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-104 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB3 (HMGB3C23hC45hC104h), 2- disulfide HMGB3 (HMGB3C23-C45C104h) and 3- sulfonyl HMGB3 (HMGB3C23soC45soC104so).
Function Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling.
Protein Name High Mobility Group Protein B3
High Mobility Group Protein 2a
Hmg-2a
High Mobility Group Protein 4
Hmg-4
Database Links
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Alternative Protein Names High Mobility Group Protein B3 protein
High Mobility Group Protein 2a protein
Hmg-2a protein
High Mobility Group Protein 4 protein
Hmg-4 protein
HMGB3 protein
HMG2A protein
HMG4 protein

Information sourced from Uniprot.org

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