Human HMBS protein (Recombinant) (His-Tag) (STJP017556)

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STJP017556
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HMBS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 0.1M NaCl
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: HMBS
Gene ID: 3145
Uniprot ID: HEM3_HUMAN
Immunogen Region: 1-361aa
Accession Number: NP_000181
Immunogen: Human
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMSGNGN AAATAEENSP KMRVIRVGTR KSQLARIQTD SVVATLKASY PGLQFEIIAM STTGDKILDT ALSKIGEKSL FTKELEHALE KNEVDLVVHS LKDLPTVLPP GFTIGAICKR ENPHDAVVFH PKFVGKTLET LPEKSVVGTS SLRRAAQLQR KFPHLEFRSI RGNLNTRLRK LDEQQEFSAI ILATAGLQRM GWHNRVGQ
Tissue Specificity Isoform 1: Is ubiquitously expressed. Isoform 2: Is found only in erythroid cells.
Function As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact.
Protein Name Porphobilinogen Deaminase
Pbg-D
Hydroxymethylbilane Synthase
Hmbs
Pre-Uroporphyrinogen Synthase
Database Links Reactome: R-HSA-189451
Cellular Localisation Cytoplasm
Cytosol
Alternative Protein Names Porphobilinogen Deaminase protein
Pbg-D protein
Hydroxymethylbilane Synthase protein
Hmbs protein
Pre-Uroporphyrinogen Synthase protein
HMBS protein
PBGD protein
UPS protein

Information sourced from Uniprot.org

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