Human HINT1 protein (Recombinant) (N-His) (STJP007428)

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STJP007428
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HINT1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HINT1
Gene ID: 3094
Uniprot ID: HINT1_HUMAN
Immunogen Region: Met1-Gly126
Immunogen: Homo sapiens (Human)
Function Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2. Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Hydrolyzes 3-indolepropionic acyl-adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RGS17. Deconjugates SUMO1 from RANGAP1.
Protein Name Adenosine 5'-Monophosphoramidase Hint1
Desumoylating Isopeptidase Hint1
Histidine Triad Nucleotide-Binding Protein 1
Protein Kinase C Inhibitor 1
Protein Kinase C-Interacting Protein 1
Pkci-1
Database Links Reactome: R-HSA-9824594
Reactome: R-HSA-9825892
Reactome: R-HSA-9856649
Cellular Localisation Cytoplasm
Nucleus
Interaction With Cdk7 Leads To A More Nuclear Localization
Alternative Protein Names Adenosine 5'-Monophosphoramidase Hint1 protein
Desumoylating Isopeptidase Hint1 protein
Histidine Triad Nucleotide-Binding Protein 1 protein
Protein Kinase C Inhibitor 1 protein
Protein Kinase C-Interacting Protein 1 protein
Pkci-1 protein
HINT1 protein
HINT protein
PKCI1 protein
PRKCNH1 protein

Information sourced from Uniprot.org

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