Human HGAL/GCSAM protein (Recombinant) (His-Tag) (STJP017915)

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STJP017915
€161.40 - €886.20
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HGAL/GCSAM-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% Glycerol, 1mM DTT
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: GCSAM
Gene ID: 257144
Uniprot ID: GCSAM_HUMAN
Immunogen Region: 1-178aa
Accession Number: NP_689998
Immunogen: Human
Immunogen Sequence: MGNSLLR ENRRQQNTQE MPWNVRMQSP KQRTSRCWDH HIAEGCFCLP WKKILIFEKR QDSQNENERM SSTPIQDNVD QTYSEELCYT LINHRVLCTR PSGNSAEEYY ENVPCKAERP RESLGGTETE YSLLHMPSTD PRHARSPEDE YELLMPHRIS SHFLQQPRPL MAPSETQFSH L
Tissue Specificity Expressed in diffuse large B-cell lymphoma (DLBCL) and several germinal center (GC)-like lymphoma cell lines (at protein level). Highly expressed in normal GC lymphocytes and GC-derived malignancies. Expressed in thymus and spleen.
Post Translational Modifications Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation.
Function Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation.
Protein Name Germinal Center-Associated Signaling And Motility Protein
Germinal Center B-Cell-Expressed Transcript 2 Protein
Germinal Center-Associated Lymphoma Protein
Hgal
Database Links
Cellular Localisation Cytoplasm
Cell Membrane
It Relocalizes From The Cytoplasm To Podosome-Like Structures Upon Cell Treatment With Il6
Alternative Protein Names Germinal Center-Associated Signaling And Motility Protein protein
Germinal Center B-Cell-Expressed Transcript 2 Protein protein
Germinal Center-Associated Lymphoma Protein protein
Hgal protein
GCSAM protein
GAL protein
GCET2 protein

Information sourced from Uniprot.org

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