| Tissue Specificity | Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. |
| Function | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Protein Hexim1Cardiac Lineage Protein 1Estrogen Down-Regulated Gene 1 ProteinHexamethylene Bis-Acetamide-Inducible Protein 1Menage A Quatre Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmBinds Alpha-Importin And Is Mostly Nuclear |
| Alternative Protein Names | Protein Hexim1 proteinCardiac Lineage Protein 1 proteinEstrogen Down-Regulated Gene 1 Protein proteinHexamethylene Bis-Acetamide-Inducible Protein 1 proteinMenage A Quatre Protein 1 proteinHEXIM1 proteinCLP1 proteinEDG1 proteinHIS1 proteinMAQ1 protein |
Information sourced from Uniprot.org
