Human HEXB protein (Recombinant) (N-His) (STJP003800)

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STJP003800
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HEXB-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HEXB
Gene ID: 3074
Uniprot ID: HEXB_HUMAN
Immunogen Region: Lys315-Tyr456
Immunogen: Homo sapiens (Human)
Function Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida.
Protein Name Beta-Hexosaminidase Subunit Beta
Beta-N-Acetylhexosaminidase Subunit Beta
Hexosaminidase Subunit B
Cervical Cancer Proto-Oncogene 7 Protein
Hcc-7
N-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A
Database Links Reactome: R-HSA-2022857
Reactome: R-HSA-2024101
Reactome: R-HSA-2160916
Reactome: R-HSA-3656248
Reactome: R-HSA-6798695
Reactome: R-HSA-9840310
Cellular Localisation Lysosome
Cytoplasmic Vesicle
Secretory Vesicle
Cortical Granule
Alternative Protein Names Beta-Hexosaminidase Subunit Beta protein
Beta-N-Acetylhexosaminidase Subunit Beta protein
Hexosaminidase Subunit B protein
Cervical Cancer Proto-Oncogene 7 Protein protein
Hcc-7 protein
N-Acetyl-Beta-Glucosaminidase Subunit Beta Cleaved Into - Beta-Hexosaminidase Subunit Beta Chain B - Beta-Hexosaminidase Subunit Beta Chain A protein
HEXB protein
HCC7 protein

Information sourced from Uniprot.org

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