Human HEPACAM2 protein (Recombinant) (N-His) (STJP011014)

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STJP011014
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HEPACAM2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HEPACAM2
Gene ID: 253012
Uniprot ID: HECA2_HUMAN
Immunogen Region: Leu32-Pro351
Immunogen: Homo sapiens (Human)
Post Translational Modifications Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes. N-glycosylated.
Function Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation.
Protein Name Hepacam Family Member 2
Mitotic Kinetics Regulator
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type I Membrane Protein
Cytoplasm
Cytoskeleton
Spindle
Microtubule Organizing Center
Centrosome
Midbody
In Interphase
Localizes To The Golgi Apparatus
Localizes To Centrosomes And Spindles During Prophase
Prometaphase
And Metaphase Of Mitosis
And To Midbodies At Telophase
Translocation To Mitotic Centrosomes Is The Result Of Poly-Adp-Ribosylation (Parsylation)
Alternative Protein Names Hepacam Family Member 2 protein
Mitotic Kinetics Regulator protein
HEPACAM2 protein
MIKI protein
UNQ305 protein
PRO346 protein

Information sourced from Uniprot.org

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