| Post Translational Modifications | Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4. |
| Function | Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones. |
| Protein Name | Histone Deacetylase 8Hd8Protein Deacetylase Hdac8Protein Decrotonylase Hdac8 |
| Database Links | Reactome: R-HSA-2122947Reactome: R-HSA-2467813 Q9BY41-1Reactome: R-HSA-2500257 Q9BY41-1Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-3214815Reactome: R-HSA-350054 |
| Cellular Localisation | NucleusChromosomeCytoplasmExcluded From The NucleoliFound In The Cytoplasm Of Cells Showing Smooth Muscle Differentiation |
| Alternative Protein Names | Histone Deacetylase 8 proteinHd8 proteinProtein Deacetylase Hdac8 proteinProtein Decrotonylase Hdac8 proteinHDAC8 proteinHDACL1 proteinCDA07 protein |
Information sourced from Uniprot.org
