Human HCII (Heparin Cofactor II) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015787)
SPECIFICATIONS
General Information
| Short Description | This HCII Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human plasma.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.067ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | SERPIND1 |
| Gene ID | 3053 |
| Uniprot ID | HEP2_HUMAN |
| Immunogen Region | Ready-To-Use |
| Sample Type | plasma. |
Additional Info
| Tissue Specificity | Expressed predominantly in liver. Also present in plasma. Isoform 2: Expressed in plasma (at protein level). Expressed in liver. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. Isoform 2: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro. |
| Protein Name | Heparin Cofactor 2Heparin Cofactor IiHc-IiProtease Inhibitor Leuserpin-2Hls2Serpin D1 |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | |
| Alternative ELISA Names | Heparin Cofactor 2 ELISA kitHeparin Cofactor Ii ELISA kitHc-Ii ELISA kitProtease Inhibitor Leuserpin-2 ELISA kitHls2 ELISA kitSerpin D1 ELISA kitSERPIND1 ELISA kitHCF2 ELISA kit |
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Information sourced from Uniprot.org