Tissue Specificity | Expressed predominantly in liver. Also present in plasma. Isoform 2: Expressed in plasma (at protein level). Expressed in liver. |
Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
Function | Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. Isoform 2: Shows negligible inhibition, in vitro, of thrombin and tPA and no inhibition of factor Xa, in vitro. |
Protein Name | Heparin Cofactor 2Heparin Cofactor IiHc-IiProtease Inhibitor Leuserpin-2Hls2Serpin D1 |
Database Links | Reactome: R-HSA-140837Reactome: R-HSA-140875Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
Cellular Localisation | |
Alternative ELISA Names | Heparin Cofactor 2 ELISA kitHeparin Cofactor Ii ELISA kitHc-Ii ELISA kitProtease Inhibitor Leuserpin-2 ELISA kitHls2 ELISA kitSerpin D1 ELISA kitSERPIND1 ELISA kitHCF2 ELISA kit |
output | |
Information sourced from Uniprot.org