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Human HB-EGF protein (Recombinant) (C-His) (STJP002661)

Human HB-EGF protein (Recombinant) (C-His) (STJP002661)

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STJP002661

£80.50 - £274.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 1 EU/Mu g of the protein by LAL method.
Immunoreactivity:	Measured in a cell proliferation assay using Balb3T3 mouse fibroblast cells. The ED₅₀ for this effect is 0.15-0.60 ng/mL, corresponding to a specific activity of 1.67×10⁶~6.67×10⁶ units/mg.

Gene Symbol:	HBEGF
Gene ID:	1839
Uniprot ID:	HBEGF_HUMAN
Immunogen Region:	Leu20-Leu148
Immunogen:	Recombinant Human HB-EGF Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Leu20-Leu148) of human HB-EGF (Accession #Q99075) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	LVTGESLERLRRGLAAGTSN PDPPTVSTDQLLPLGGGRDR KVRDLQEADLDLLRVTLSSK PQALATPNKEEHGKRKKKGK GLGKKRDPCLRKYKDFCIHG ECKYVKELRAPSCICHPGYH GERCHGLSL

Function	Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
Protein Name	Proheparin-Binding Egf-Like Growth Factor Cleaved Into - Heparin-Binding Egf-Like Growth Factor Hb-Egf Hbegf Diphtheria Toxin Receptor Dt-R
Database Links	Reactome: R-HSA-1227986 Reactome: R-HSA-1236394 Reactome: R-HSA-1250196 Reactome: R-HSA-1250342 Reactome: R-HSA-1250347 Reactome: R-HSA-1251985 Reactome: R-HSA-1257604 Reactome: R-HSA-177929 Reactome: R-HSA-179812 Reactome: R-HSA-180292 Reactome: R-HSA-180336 Reactome: R-HSA-182971 Reactome: R-HSA-1963640 Reactome: R-HSA-1963642 Reactome: R-HSA-212718 Reactome: R-HSA-2179392 Reactome: R-HSA-2219530 Reactome: R-HSA-5336415 Reactome: R-HSA-5638303 Reactome: R-HSA-5673001 Reactome: R-HSA-6785631 Reactome: R-HSA-6811558 Reactome: R-HSA-8847993 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8857538 Reactome: R-HSA-8863795 Reactome: R-HSA-9009391 Reactome: R-HSA-9634638 Reactome: R-HSA-9664565 Reactome: R-HSA-9665686
Cellular Localisation	Heparin-Binding Egf-Like Growth Factor: Secreted Extracellular Space Mature Hb-Egf Is Released Into The Extracellular Space And Probably Binds To A Receptor Proheparin-Binding Egf-Like Growth Factor: Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Proheparin-Binding Egf-Like Growth Factor Cleaved Into - Heparin-Binding Egf-Like Growth Factor protein Hb-Egf protein Hbegf protein Diphtheria Toxin Receptor protein Dt-R protein HBEGF protein DTR protein DTS protein HEGFL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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