| Host: | HEK293 Cells |
| Applications: | SDS-PAGE/Bioactivity |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human HAPLN1-His-Tag protein was developed from hek293 cells and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol |
| Concentration: | 0.25 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Endotoxin: | < 1 EU per 1ug of protein (determined by LAL method) |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA with Hyaluronic acid. The ED50 range ≤ 1 ug/ml. |
| Gene Symbol: | HAPLN1 |
| Gene ID: | 1404 |
| Uniprot ID: | HPLN1_HUMAN |
| Immunogen Region: | 16-354aa |
| Accession Number: | NP_001875.1 |
| Immunogen: | Human |
| Immunogen Sequence: | DHLSDNYTLD HDRAIHIQAE NGPHLLVEAE QAKVFSHRGG NVTLPCKFYR DPTAFGSGIH KIRIKWTKLT SDYLKEVDVF VSMGYHKKTY GGYQGRVFLK GGSDSDASLV ITDLTLEDYG RYKCEVIEGL EDDTVVVALD LQGVVFPYFP RLGRYNLNFH EAQQACLDQD AVIASFDQLY DAWRGGLDWC NAGWLSDGSV QYPITKPREP CGGQNTVPGV RNYGFWDK |
| Tissue Specificity | Widely expressed. Weakly expressed in the brain. |
| Function | Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix. |
| Protein Name | Hyaluronan And Proteoglycan Link Protein 1Cartilage-Linking Protein 1Cartilage-Link ProteinProteoglycan Link Protein |
| Database Links | Reactome: R-HSA-3000178 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Hyaluronan And Proteoglycan Link Protein 1 proteinCartilage-Linking Protein 1 proteinCartilage-Link Protein proteinProteoglycan Link Protein proteinHAPLN1 proteinCRTL1 protein |
Information sourced from Uniprot.org