| Function | Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. |
| Protein Name | Heart- And Neural Crest Derivatives-Expressed Protein 2Class A Basic Helix-Loop-Helix Protein 26Bhlha26Deciduum - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 2Dhand |
| Database Links | Reactome: R-HSA-8878166Reactome: R-HSA-9733709 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Heart- And Neural Crest Derivatives-Expressed Protein 2 proteinClass A Basic Helix-Loop-Helix Protein 26 proteinBhlha26 proteinDeciduum - Heart - Autonomic Nervous System And Neural Crest Derivatives-Expressed Protein 2 proteinDhand proteinHAND2 proteinBHLHA26 proteinDHAND protein |
Information sourced from Uniprot.org