Human HADH protein (Recombinant) (N-His) (STJP005525)

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STJP005525
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human HADH-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: HADH
Gene ID: 3033
Uniprot ID: HCDH_HUMAN
Immunogen Region: Met1-Arg236
Immunogen: Homo sapiens (Human)
Post Translational Modifications Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5.
Function Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes.
Protein Name Hydroxyacyl-Coenzyme A Dehydrogenase - Mitochondrial
Hcdh
Medium And Short-Chain L-3-Hydroxyacyl-Coenzyme A Dehydrogenase
Short-Chain 3-Hydroxyacyl-Coa Dehydrogenase
Database Links Reactome: R-HSA-77310
Reactome: R-HSA-77346
Reactome: R-HSA-77348
Reactome: R-HSA-77350
Reactome: R-HSA-77352
Reactome: R-HSA-9837999
Cellular Localisation Mitochondrion Matrix
Alternative Protein Names Hydroxyacyl-Coenzyme A Dehydrogenase - Mitochondrial protein
Hcdh protein
Medium And Short-Chain L-3-Hydroxyacyl-Coenzyme A Dehydrogenase protein
Short-Chain 3-Hydroxyacyl-Coa Dehydrogenase protein
HADH protein
HAD protein
HAD1 protein
HADHSC protein
SCHAD protein

Information sourced from Uniprot.org