| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human H4C1-N-His-SUMO & C-Strep protein was developed from e. coli and has a target region of N-His-SUMO & C-Strep. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | H4C1.H4C2.H4C3.H4C4.H4C5.H4C6.H4C8.H4C9.H4C11.H4C12.H4C13.H4C14.H4C15.H4C16 |
| Gene ID: | 121504/554313/8294/8359/8360/8361/8362/8363/8364/8365/8366/8367/8368/8370 |
| Uniprot ID: | H4_HUMAN |
| Immunogen Region: | Asn26-Gly103 |
| Immunogen: | Homo sapiens (Human) |
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Protein Name | Histone H4 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-1912408Reactome: R-HSA-201722Reactome: R-HSA-212300Reactome: R-HSA-2299718Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2559586Reactome: R-HSA-3214815Reactome: R-HSA-3214841Reactome: R-HSA-3214842Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-427359Reactome: R-HSA-427389Reactome: R-HSA-427413Reactome: R-HSA-4551638Reactome: R-HSA-5250924Reactome: R-HSA-5334118Reactome: R-HSA-5578749Reactome: R-HSA-5617472Reactome: R-HSA-5625886Reactome: R-HSA-5693565Reactome: R-HSA-5693571Reactome: R-HSA-5693607Reactome: R-HSA-606279Reactome: R-HSA-68616Reactome: R-HSA-69473Reactome: R-HSA-73728Reactome: R-HSA-73772Reactome: R-HSA-8936459Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-912446Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9616222Reactome: R-HSA-9670095Reactome: R-HSA-9710421Reactome: R-HSA-977225Reactome: R-HSA-9821002Reactome: R-HSA-9821993Reactome: R-HSA-9843940Reactome: R-HSA-9843970Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusChromosome |
| Alternative Protein Names | Histone H4 proteinH4C1 proteinH4 proteinA proteinH4FA proteinHIST1H4A.H4C2 proteinH4 proteinI proteinH4FI proteinHIST1H4B.H4C3 proteinH4 proteinG proteinH4FG proteinHIST1H4C.H4C4 proteinH4 proteinB proteinH4FB proteinHIST1H4D.H4C5 proteinH4 proteinJ proteinH4FJ proteinHIST1H4E.H4C6 proteinH4 proteinC proteinH4FC proteinHIST1H4F.H4C8 proteinH4 proteinH proteinH4FH proteinHIST1H4H.H4C9 proteinH4 proteinM proteinH4FM proteinHIST1H4I.H4C11 proteinH4 proteinE proteinH4FE proteinHIST1H4J.H4C12 proteinH4 proteinD proteinH4FD proteinHIST1H4K.H4C13 proteinH4 proteinK proteinH4FK proteinHIST1H4L.H4C14 proteinH4 proteinN proteinH4F2 proteinH4FN proteinHIST2H4 proteinHIST2H4A.H4C15 proteinH4 proteinO proteinH4FO proteinHIST2H4B.H4C16 proteinH4-16 proteinHIST4H4 protein |
Information sourced from Uniprot.org