Human GUCY2C/GCC protein (Recombinant-Active) (C-His) (STJP011935)

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STJP011935-100
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Covered by St John's Laboratory Guarantee

Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Human GUCY2C/GCC-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: GUCY2C
Gene ID: 2984
Uniprot ID: GUC2C_HUMAN
Immunogen Region: Ser24-Gln430
Immunogen: Homo sapiens (Human)
Function Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C. Also activated by the endogenous peptides guanylin and uroguanylin.
Protein Name Guanylyl Cyclase C
Gc-C
Heat-Stable Enterotoxin Receptor
Sta Receptor
Hstar
Intestinal Guanylate Cyclase
Database Links Reactome: R-HSA-8935690
Reactome: R-HSA-8942233
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
The 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose Residues
While A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form
Alternative Protein Names Guanylyl Cyclase C protein
Gc-C protein
Heat-Stable Enterotoxin Receptor protein
Sta Receptor protein
Hstar protein
Intestinal Guanylate Cyclase protein
GUCY2C protein
GUC2C protein
STAR protein

Information sourced from Uniprot.org

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