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Human GTPase KRas/KRAS protein (Recombinant) (N-His) (STJP001251)

Human GTPase KRas/KRAS protein (Recombinant) (N-His) (STJP001251)

Human GTPase KRas/KRAS protein (Recombinant) (N-His) (STJP001251)

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STJP001251

€90.63 - €279.38

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General Information
Product Properties
Target Information
Additional Info
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Host:	E. coli
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 1.0 EU/Mu g of the protein by LAL method.

Gene Symbol:	KRAS
Gene ID:	3845
Uniprot ID:	RASK_HUMAN
Immunogen:	Recombinant Human GTPase KRas/KRAS Protein is produced by E. coli expression system. The target protein is expressed with sequence (Thr2-Cys186) of human GTPase KRas/KRAS (Accession #NP_203524.1) fused with a 6×His tag at the N-terminus.
Immunogen Sequence:	TEYKLVVVGAGGVGKSALTI QLIQNHFVDEYDPTIEDSYR KQVVIDGETCLLDILDTAGQ EEYSAMRDQYMRTGEGFLCV FAINNTKSFEDIHHYREQIK RVKDSEDVPMVLVGNKCDLP SRTVDTKQAQDLARSYGIPF IETSAKTRQRVEDAFYTLVR EIRQYRLKKISKEEKTPGCV KIKKC

Function	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
Protein Name	Gtpase Kras K-Ras 2 Ki-Ras C-K-Ras C-Ki-Ras Cleaved Into - Gtpase Kras - N-Terminally Processed
Database Links	Reactome: R-HSA-112412 Reactome: R-HSA-1169092 Reactome: R-HSA-1236382 Reactome: R-HSA-1250196 Reactome: R-HSA-1250347 Reactome: R-HSA-1433557 Reactome: R-HSA-167044 Reactome: R-HSA-171007 Reactome: R-HSA-179812 Reactome: R-HSA-180336 Reactome: R-HSA-186763 Reactome: R-HSA-1963640 Reactome: R-HSA-210993 Reactome: R-HSA-2179392 Reactome: R-HSA-2424491 Reactome: R-HSA-2428933 Reactome: R-HSA-2871796 Reactome: R-HSA-375165 Reactome: R-HSA-4086398 P01116-2 Reactome: R-HSA-442982 Reactome: R-HSA-5218921 Reactome: R-HSA-5621575 Reactome: R-HSA-5637810 Reactome: R-HSA-5654688 Reactome: R-HSA-5654693 Reactome: R-HSA-5654699 Reactome: R-HSA-5654700 Reactome: R-HSA-5654704 Reactome: R-HSA-5654706 Reactome: R-HSA-5654712 Reactome: R-HSA-5654719 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-5658442 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-5674135 Reactome: R-HSA-5675221 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802953 Reactome: R-HSA-6802955 Reactome: R-HSA-74751 Reactome: R-HSA-8849471 Reactome: R-HSA-8851805 Reactome: R-HSA-8951936 Reactome: R-HSA-9026519 Reactome: R-HSA-9027284 Reactome: R-HSA-9028731 Reactome: R-HSA-9034864 Reactome: R-HSA-9607240 Reactome: R-HSA-9634285 Reactome: R-HSA-9634635 Reactome: R-HSA-9648002 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9664565 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9670439 Reactome: R-HSA-9673767 Reactome: R-HSA-9673770 Reactome: R-HSA-9674555 Reactome: R-HSA-9680350 Reactome: R-HSA-9703465 Reactome: R-HSA-9703648 Reactome: R-HSA-9753510 Reactome: R-HSA-9753512
Cellular Localisation	Cell Membrane Lipid-Anchor Cytoplasmic Side Endomembrane System Cytoplasm Cytosol Isoform 2b: Cell Membrane
Alternative Protein Names	Gtpase Kras protein K-Ras 2 protein Ki-Ras protein C-K-Ras protein C-Ki-Ras Cleaved Into - Gtpase Kras - N-Terminally Processed protein KRAS protein KRAS2 protein RASK2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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