Human GTPase KRas/KRAS (G12V) protein (Recombinant) (N-His) (STJP001252)

Name: Human GTPase KRas/KRAS (G12V) protein (Recombinant) (N-His) (STJP001252)
SKU: STJP001252
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

HostE.coli

ConjugationUnconjugated

ImmunogenRecombinant Human GTPase KRas/KRAS (G12V) Protein is produced by E. coli expression system. The target protein is expressed with sequence (Thr2-Cys186 (Gly12Val) ) of human GTPase KRas/KRAS (Accession #NP_203524.1) fused with a 6×His tag at the N-ter

STJP001252

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General Information

Short Description	Recombinant-Human GTPase KRas/KRAS (G12V)-N-His protein was developed in e.coli using the region Thr2-Cys186. For use in research applications.
Host	E.coli
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

Conjugation	Unconjugated
Formulation	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity	Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human KRAS, His Tag at 2 Mu g/mL (100 Mu L/well) can bind Anti-KRAS Ab with a linear range of 42-84.56 ng/mL.
Determination Method	< 1.0 EU/Mu g of the protein by LAL method.

Target Information

Gene Symbol	KRAS
Gene ID	3845
Uniprot ID	RASK_HUMAN
Immunogen	Recombinant Human GTPase KRas/KRAS (G12V) Protein is produced by E. coli expression system. The target protein is expressed with sequence (Thr2-Cys186 (Gly12Val) ) of human GTPase KRas/KRAS (Accession #NP_203524.1) fused with a 6×His tag at the N-ter
Immunogen Region	Thr2-Cys186
Immunogen Sequence	TEYKLVVVGAVGVGKSALTI QLIQNHFVDEYDPTIEDSYR KQVVIDGETCLLDILDTAGQ EEYSAMRDQYMRTGEGFLCV FAINNTKSFEDIHHYREQIK RVKDSEDVPMVLVGNKCDLP SRTVDTKQAQDLARSYGIPF IETSAKTRQRVEDAFYTLVR EIRQYRLKKISKEEKTPGCV KIKKC

Additional Info

Function	Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner.
Protein Name	Gtpase Kras K-Ras 2 Ki-Ras C-K-Ras C-Ki-Ras Cleaved Into - Gtpase Kras - N-Terminally Processed
Database Links	Reactome: R-HSA-112412 Reactome: R-HSA-1169092 Reactome: R-HSA-1236382 Reactome: R-HSA-1250196 Reactome: R-HSA-1250347 Reactome: R-HSA-1433557 Reactome: R-HSA-167044 Reactome: R-HSA-171007 Reactome: R-HSA-179812 Reactome: R-HSA-180336 Reactome: R-HSA-186763 Reactome: R-HSA-1963640 Reactome: R-HSA-210993 Reactome: R-HSA-2179392 Reactome: R-HSA-2424491 Reactome: R-HSA-2428933 Reactome: R-HSA-2871796 Reactome: R-HSA-375165 Reactome: R-HSA-4086398 P01116-2 Reactome: R-HSA-442982 Reactome: R-HSA-5218921 Reactome: R-HSA-5621575 Reactome: R-HSA-5637810 Reactome: R-HSA-5654688 Reactome: R-HSA-5654693 Reactome: R-HSA-5654699 Reactome: R-HSA-5654700 Reactome: R-HSA-5654704 Reactome: R-HSA-5654706 Reactome: R-HSA-5654712 Reactome: R-HSA-5654719 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-5658442 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-5674135 Reactome: R-HSA-5675221 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802953 Reactome: R-HSA-6802955 Reactome: R-HSA-74751 Reactome: R-HSA-8849471 Reactome: R-HSA-8851805 Reactome: R-HSA-8951936 Reactome: R-HSA-9026519 Reactome: R-HSA-9027284 Reactome: R-HSA-9028731 Reactome: R-HSA-9034864 Reactome: R-HSA-9607240 Reactome: R-HSA-9634285 Reactome: R-HSA-9634635 Reactome: R-HSA-9648002 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9664565 Reactome: R-HSA-9665348 Reactome: R-HSA-9665686 Reactome: R-HSA-9670439 Reactome: R-HSA-9673767 Reactome: R-HSA-9673770 Reactome: R-HSA-9674555 Reactome: R-HSA-9680350 Reactome: R-HSA-9703465 Reactome: R-HSA-9703648 Reactome: R-HSA-9753510 Reactome: R-HSA-9753512
Cellular Localisation	Cell Membrane Lipid-Anchor Cytoplasmic Side Endomembrane System Cytoplasm Cytosol Isoform 2b: Cell Membrane
Alternative Protein Names	Gtpase Kras protein K-Ras 2 protein Ki-Ras protein C-K-Ras protein C-Ki-Ras Cleaved Into - Gtpase Kras - N-Terminally Processed protein KRAS protein KRAS2 protein RASK2 protein

Information sourced from Uniprot.org

Citations

View product citations for antibody STJP001252 on CiteAb