Human GSN protein (Recombinant) (C-mFc) (STJP013109)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human GSN-C-mFc protein was developed from mammalian cells and has a target region of C-mFc. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, 1mM DTT, 5% Trehalose, 0.1% Triton X-100, pH 8.0. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8ยฐC for one week. Store at-20 to-80ยฐC for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/ยตg as determined by LAL test. |
Target Information
| Gene Symbol | GSN |
| Gene ID | 2934 |
| Uniprot ID | GELS_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala28-Ala782 |
Additional Info
| Post Translational Modifications | Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids. |
| Function | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. |
| Protein Name | GelsolinAgelActin-Depolymerizing FactorAdfBrevin |
| Database Links | Reactome: R-HSA-264870Reactome: R-HSA-6798695Reactome: R-HSA-9662361Reactome: R-HSA-977225 |
| Cellular Localisation | Isoform 2: CytoplasmCytoskeletonIsoform 1: Secreted |
| Alternative Protein Names | Gelsolin proteinAgel proteinActin-Depolymerizing Factor proteinAdf proteinBrevin proteinGSN protein |
Information sourced from Uniprot.org