| Host: | Mammalian Cells |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human GSN-C-mFc protein was developed from mammalian cells and has a target region of C-mFc. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilized from a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, 1mM DTT, 5% Trehalose, 0.1% Triton X-100, pH 8.0. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | < 1 EU/µg as determined by LAL test. |
| Gene Symbol: | GSN |
| Gene ID: | 2934 |
| Uniprot ID: | GELS_HUMAN |
| Immunogen Region: | Ala28-Ala782 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids. |
| Function | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. |
| Protein Name | GelsolinAgelActin-Depolymerizing FactorAdfBrevin |
| Database Links | Reactome: R-HSA-264870Reactome: R-HSA-6798695Reactome: R-HSA-9662361Reactome: R-HSA-977225 |
| Cellular Localisation | Isoform 2: CytoplasmCytoskeletonIsoform 1: Secreted |
| Alternative Protein Names | Gelsolin proteinAgel proteinActin-Depolymerizing Factor proteinAdf proteinBrevin proteinGSN protein |
Information sourced from Uniprot.org