Human GRK4 protein (Recombinant) (N-His) (STJP004563)

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STJP004563
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GRK4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GRK4
Gene ID: 2868
Uniprot ID: GRK4_HUMAN
Immunogen Region: Arg188-Phe449
Immunogen: Homo sapiens (Human)
Post Translational Modifications Palmitoylated.
Function Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin.the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Protein Name G Protein-Coupled Receptor Kinase 4
G Protein-Coupled Receptor Kinase Grk4
Iti1
Database Links Reactome: R-HSA-2514859 P32298-1
Cellular Localisation Cytoplasm
Cell Cortex
Both At The Cell Surface And Dispersed In The Cytoplasm Under Basal Conditions
Receptor Stimulation Results In The Internalization Of Grk4 To The Perinuclear Area
Where Colocalization With Drd3 Is Observed Strongly At 5 And 15 Minutes
Drd3 And Grk4 Colocalize In Lipid Rafts Of Renal Proximal Tubule Cells
Alternative Protein Names G Protein-Coupled Receptor Kinase 4 protein
G Protein-Coupled Receptor Kinase Grk4 protein
Iti1 protein
GRK4 protein
GPRK2L protein
GPRK4 protein

Information sourced from Uniprot.org

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