Human GRK2 protein (Recombinant) (N-GST) (STJP004413)

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STJP004413
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human GRK2-N-GST protein was developed from e. coli and has a target region of N-GST. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: GRK2
Gene ID: 156
Uniprot ID: ARBK1_HUMAN
Immunogen Region: Asp398-Leu640
Immunogen: Homo sapiens (Human)
Function Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Inhibits relaxation of airway smooth muscle in response to blue light.
Protein Name Beta-Adrenergic Receptor Kinase 1
Beta-Ark-1
G-Protein Coupled Receptor Kinase 2
Database Links Reactome: R-HSA-111933
Reactome: R-HSA-416476
Reactome: R-HSA-418555
Reactome: R-HSA-5635838
Reactome: R-HSA-8856825
Cellular Localisation Cytoplasm
Cell Membrane
Postsynapse
Presynapse
Alternative Protein Names Beta-Adrenergic Receptor Kinase 1 protein
Beta-Ark-1 protein
G-Protein Coupled Receptor Kinase 2 protein
GRK2 protein
ADRBK1 protein
BARK protein
BARK1 protein

Information sourced from Uniprot.org

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